Most drugs of abuse are addictive. Addiction is a chronic, relapsing disease characterized by compulsive drug seeking and use despite negative consequences and by long-lasting changes in the brain. People who are addicted have strong cravings for the drug, making it difficult to stop using. Most drugs alter a person’s thinking and judgment, which can increase the risk of injury or death from drugged driving or infectious diseases (., HIV/AIDS, hepatitis) from unsafe sexual practices or needle sharing. Drug use during pregnancy can lead to neonatal abstinence syndrome, a condition in which a baby can suffer from dependence and withdrawal symptoms after birth. Pregnancy-related issues are listed in the chart below for drugs where there is enough scientific evidence to connect the drug use to negative effects. However, most drugs could potentially harm an unborn baby.
Noxious input to the spinal cord is known to produce central sensitization, which consists of allodynia , exaggeration of pain, and punctuate hyperalgesia , extreme sensitivity to pain. Two types of mechanical hyperalgesia can occur: 1) touch that is normally painless in the uninjured surroundings of a cut or tear can trigger painful sensations (touch-evoked hyperalgesia), and 2) a slightly painful pin prick stimulation is perceived as more painful around a focused area of inflammation (punctuate hyperalgesia). Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require continuous firing which means it can persist for hours after a trauma and can be stronger than normally experienced. In addition, it was found that patients with neuropathic pain, histamine ionophoresis resulted in a sensation of burning pain rather than itch, which would be induced in normal healthy patients. This shows that there is spinal hypersensitivity to C-fiber input in chronic pain. 
Winstrol is a brand name of the synthetic anabolic steroid, stanozolol. Although no longer available in the . under the name of Winstrol, generic versions of stanozolol can still be found. Stanozolol is similar to testosterone and commonly used by veterinarians on debilitated animals (especially dogs and horses) to improve muscle growth, trigger red blood cell production, increase bone density and enhance appetite. It's approved by the . Food and Drug Administration (FDA) for treating anemia and hereditary angioedema (swelling of blood vessels) in people, although a prescription is needed. Winstrol (stanozolol) is a banned performance-enhancing drug, but still used widely by track and field athletes as well as bodybuilders — usually illegally. You should take stanozolol only with the permission and under the care of a physician.